Diagnóstico Genético Preimplantacional de Aneuploidías

PGT-A
Preimplantation Genetic Testing for
Aneuploidy

PGT-A (Preimplantation Genetic Testing for Aneuploidy) is a procedure that allows the determination of the chromosomal state of IVF embryos by screening all 23 pairs of human chromosomes. Only embryos with the correct number of chromosomes will beable to implant and develop into a healthy baby.

Our PGT-A test uses the latest next generation sequencing (NGS) technology to identify those embryos free from chromosome abnormalities, increasing the likelihood of pregnancy per transfer, reducing the risk of miscarriage and allowing confident single embryo transfer.

Process
The test PGT-A  identifies the best embryos for successful transfer, reducing the risk of miscarriage.
Biopsia del embrión en estadio de blastocito
Introducción de las células biopsiadas en el tubo PGT-A
Envío de las
muestras a 4ºC
Análisis del ADN de las células biopsiadas
Resultados en
10 días laborables
Process
The test PGT-A  identifies the best embryos for successful transfer, reducing the risk of miscarriage.

Increases the probability of reproductive success

YOUR PROCESS

Add quality and confidence to your assisted reproduction treatment: go one step further and include the PGT-A® test in your process.

1.

Tell your gynaecologist, he or she will show you how PGT-A® can make a difference.

2.

Your doctor will find the right option for you.

3.

Your doctor will take care of everything so that we can continue to look after you as you deserve in your journey towards motherhood.

What is chromosomal aneuploidy?

Chromosomes are DNA and proteins structures that carry our genetic information. Normal human embryos have 23 pairs of chromosomes. One copy of each chromosome pair is inherited from the mother and the other copy from the father.

Abnormalities during early development of the sperm, egg or embryo may lead to an
incorrect number of chromosomes in the embryo. These numerical anomalies in chromosome count are called aneuploidies.

Aneuploidy is responsible for the vast majority of first trimester miscarriages and has been shown to be a major cause of infertility and IVF failure (1).

Chromosomal abnormalities can occur in women of all ages, however the chances are greater with increasing maternal age (2).

Most chromosomal abnormalities are incompatible with life, leading to abortions and the rest of them are associated with genetic disorders like Down syndrome
(resultant form the presence of an extra copy of chromosome 21).

What is the PGT-A?

PGT-A (Preimplantation Genetic Testing for Aneuploidy) also known as PGS (Preimplantation Genetic Screening)
is a genetic test that allows the determination of the chromosomal state of IVF embryos by screening all 23 pairs of human chromosomes.

PGT-A test is able to identify those embryos free form chromosome abnormalities (euploid embryos) that are more likely to implant and result in a healthy live birth.

By selecting healthy embryos with the right number of chromosomes to be transferred to the uterus, PGT-A:

• Improves IVF success, increasing the likelihood of pregnancy per transfer (3).
• Reduces the risk of miscarriage (4).
• Allows for confident single embryo transfer, reducing the risks and complications associated to multiple pregnancies (5).
• Reduces time to pregnancy by allowing the identification of a normal embryo as soon as possible (6).
• It prevents the birth of babies with genetic diseases of chromosomal origin (7).

Benefits and added value

The IGLS uses next-generation sequencing technology to perform PGT-A.

Our NGS Illumina platform analyses thousands of DNA sequences that are unique to each chromosome allowing the accurate identification of extra or missing chromosomes.

This technology provides exceptional data reading and scalability and reliable results with better detection of imbalances than other available methods. Our test gives accurate answers to patients, guaranteeing the transfer of a genetically normal embryo and hence minimizing the incidence of miscarriages and birth defects caused by irregularity in the chromosome number.

Indications of PGT-A

PGT-A is a helpful technique for the vast majority of couples seeking IVF treatment. All pregnancies are at risk of chromosome abnormality. Nearly 50% of the embryos produced in an IVF cycle are aneuploid (8).

Aneuploidies are a major cause of difficulties achieving pregnancy in couples of all ages.

However, as a woman ages, the quality of her eggs decreases and her risk of producing an embryo with chromosome abnormalities increases.

This is why a woman’s age is critical for pregnancy success.

Embryo screening would improve the chances of achieving a successful pregnancy in all IVF patients. However, it is particularly suitable to help couples with recurrent pregnancy loss, couples with previous IVF failure attempts, women of advanced reproductive age (over 35 y.o.), couples with family history of chromosome problems, couples opting for confident single embryo transfer and good prognosis patients who want to avoid futile future cycles of frozen embryos.

1. Hassold T. & Hunt P. – Nat Rev Genet 2001; 2: 280-291.
2. Fragouli E. et al. – Hum Genet 2013; 132(9): 1001-13.
3. Scott R.T. et al. – Fertil Steril 2013; 100: 697-703.
4. Grifo J.A. et al. – J Assist Reprod Genet 2013; 30(2): 259-264.

5. Yang Z. et al. – Mol Cytogenet 2012; 5: 24.
6. Sermon K. et al. – Mol Hum Reprod 2016; 22(8): 845-57.
7. Fiorentino F. et al. – Hum Reprod 2011; 26(7): 1925-35.
8. Ata B. et al. – Reprod Biomed Online 2012; 24(6): 614-20.