Scientific and academic papers

Our expert team keeps abreast of industry trends. Open science strategies and academic publications support the research and development of any new techniques and processes in benefit of the permanent improvement and extension of our range of genetics and immunology services.

EUPLOID EMBRYOS SELECTED BY AN AUTOMATED TIME-LAPSE SYSTEM HAVE SUPERIOR SET OUTCOMES THAN SELECTED SOLELY BY CONVENTIONAL MORPHOLOGY ASSESSMENT

Rocafort E, Enciso M, Leza A, Sarasa J, Aizpurua J.

Journal of Assisted Reproduction and Genetics. 2018

Clinical application of a protocol based on universal next-generation sequencing for the diagnosis of beta-thalassaemia and sickle cell anaemia in preimplantation embryos

Kubikova N, Babariya D, Sarasa J, Spath K, Alfarawati S, Wells D.

RBM online. 2018

Oral antioxidant therapy improves sperm quality in patients with abnormally high levels of apoptotic spermatozoa

 

Leza A, Rocafort E, Vilella I, Medrano L, Sarasa J, Enciso M, Aizpurua J.

Hum Reprod. 2017; 32 (supp 1): i184.

New permeable cryoprotectant-free vitrification method for native human sperm

 

Aizpurua J, Medrano L, Enciso M, Sarasa J, Romero A, Fernández MA, Gómez-Torres MJ

Hum Reprod. 2017 Oct 1;32(10):2007-2015

ER Map: a new comprehensive and reliable endometrial receptivity test

 

 

Horcajadas JA, Enciso M, Sarasa J, Carrascosa JP, Martínez-Ortiz PA, Aizpurua J, & Munné S

Hum Reprod. 2016; 31 (supp 1): i49

Development of a new comprehensive and reliable endometrial receptivity map (ER Map/ER Grade) based on RT-qPCR gene expression analysis

Enciso M, Carrascosa JP, Sarasa J, Martínez-Ortiz PA, Munné S, Horcajadas JA, Aizpurua J.

Hum Reprod. 2018; Feb 1;33(2):220-228

Personalised scheduling of embryo transfer at the moment of highest endometrial receptivity according to ER Map® test significantly improves clinical outcomes

Sarasa J, Aizpurua J, Jurado I, Rodriguez-Estrada B, Garcia-Poyo MC, Climent AB, Martínez-Ortiz P, Enciso M.

Hum Reprod. 2017; 32 (supp 1): i135.

Embryo selection of euploid embryos by an automated time-lapse prediction is superior to conventional morphological analysis: a retrospective study

Rocafort E, Enciso M, Leza A, Sarasa J, Aizpurua J

Hum Reprod. 2017; 32 (supp 1): i430

ER Map allow the reliable determination of the window of implantation in infertile women

Horcajadas JA, Enciso M, Sarasa J, Carrascosa JP, Martinez P, Aizpurua J, Munne S

Fertil Steril. 2016; 106 (3): e216

Design, validation and clinical application of a novel nextgeneration sequencing protocol for detection of mitochondrial disease and simultaneous aneuploidy screening in preimplantation embryos

Spath K, Sarasa J, Babariya D, Konstantinidis M, Griffiths T, Spencer J., Turner K, McCaffrey C, Gangrade B,Child T, Grifo J, Patel S, Munne S, Wells D

Hum Reprod. 2016; 31 (supp 1) i51

Cutting-edge technology
and science at the service of
reproductive medicine.

Influence of sperm parameters on embryonic development, morphokinetics, and ART outcomes: male factor exploration in a female factor-controlled study platform

Leza A, Rocafort E, Vilella I, Medrano L, Guijarro M, Ramos B, Enciso M, Sarasa J, Fernández M, Aizpurua J

Hum Reprod. 2016; 31 (supp 1): i82

Combined time lapse imaging and preimplantation genetic screening: a valuable strategy for embryo selection

Rocafort E, Leza A, Ramos B, Guijarro M, Medrano L, Enciso M, Sarasa J, Fernández M, Aizpurua J

Hum Reprod. 2016; 31 (supp 1): i406

Oral antioxidant therapy improves sperm quality in patients with abnormally high levels of apoptotic spermatozoa

 

Leza A, Rocafort E, Vilella I, Medrano L, Sarasa J, Enciso M, Aizpurua J.

Hum Reprod. 2017; 32 (supp 1): i184.

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy

 

Enciso M, Sarasa J, Xanthopoulou L, Bristow S, Bowles M, Fragouli E, Delhanty J, Wells D

Hum Genet. 2016;135(5):555-68

Karyomapping identifies second polar body DNA persisting to the blastocyst stage: Implications for embryo biopsy

Ottolini CS, Rogers S, Sage K, Summers MC, Capalbo A, Griffin DK, Sarasa J, Wells D, Handyside AH

RBM Online. 2015. 31(6):776–782

Conventional sperm analysis: is it telling us the whole story?

Vilella Amorós I, Guijarro M, García L, Sarasa J, Enciso M, Fernández M, Aizpurua J

Hum Reprod. 2016; 31 (supp 1): i167

Development of a universal method for the preimplantation diagnosis of β-thalassemia and sickle-cell anaemia using a novel next-generation sequencing approach: a new paradigm for PGD

Kubikova N, Sarasa J, Wells D

Hum Reprod. 2016; 31 (supp 1) i402

Embryo selection of euploid embryos by an automated time-lapse prediction is superior to conventional morphological analysis: a retrospective study

Rocafort E, Enciso M, Leza A, Sarasa J, Aizpurua J

Hum Reprod. 2017; 32 (supp 1): i430

Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology

Giménez C, Sarasa J, Arjona C, Vilamajó E, Martínez-Pasarell O, Wheeler K, Valls G, Garcia-Guixé E, Wells D

RBM Online. 2015. 31(6):770-775

Specific alleles of the PRDM9 gene are a risk factor for the production of chromosomally abnormal embryos in humans

Sarasa J, Enciso M, Xanthopoulou L, Bowles M, Delhanty J, Wells D

Hum Reprod. 2013; 28 (suppl1): i108

Cutting-edge technology
and science at the service of
reproductive medicine.

The origin and impact of embryonic aneuploidy

Fragouli E, Alfarawati S, Spath K, Jaroudi S, Sarasa J, Enciso M, Wells D

 

Hum Genet. 2013;132(9):1001-13

Sperm Chromatin Integrity, DNA Fragmentation and Male Infertility

Enciso M, Wells D

New Developments in Chromatin Research. pág. 59 – 82. Nova Science Publishers Inc. 2012

Application of an optimised two tailed comet assay on human cumulus cells

Huang Z, Andonov M, Enciso M, Wells D

Hum Reprod. 2011; 26 (suppl1): i350

Major morphological sperm abnormalities in the bull are correlated with sperm DNA damage

Enciso M, Cisale H, Jonhston SD, Sarasa J, Fernández JL, Gosálvez J

Theriogenology. 2011;76(1):23-32

Effects of density gradient centrifugation and swim up techniques on sperm DNA integrit

Enciso M, Iglesias M, Galán I, Gosálvez A, Gosálvez J

Hum Reprod. 2010;25 (suppl1):i127

Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities

Enciso M, Alfarawati S, Wells D

Human Reproduction. 2013 Jun;28(6):1707-15

Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa

Enciso M, Pieczenik G, Cohen J, Wells D

 

Hum Reprod. 2012;27(8):2254-66

The ability of sperm selection techniques to remove single or double-strand DNA damage

Enciso M, Iglesias M, Galán I, Sarasa J, Gosálvez A, Gosálvez J

Asian J Androl. 2011;13(5):764-8

Differential resistance of mammalian sperm chromatin to oxidative stress as assessed by a two-tailed comet assay

Enciso M, Johnston SD, Gosálvez J

Reprod Fertil Dev. 2011;23(5):633-7

A two-tailed Comet assay for assessing DNA damage in spermatozoa

Enciso M, Sarasa J, Agarwal A, Fernández JL, Gosálvez J

Reprod Biomed Online. 2009; 18 (5): 609-16

Cutting-edge technology
and science at the service of
reproductive medicine.

Sperm DNA Fragmentation in Rams Vaccinated with Miloxan

Gosálvez J, Vázquez JM, Enciso M, Fernández JL, Gosálbez A, Bridle JR, López-Fernández C

 

Open Vet Sci J. 2008; 2:7-10

A new method to analyze boar sperm DNA fragmentation under bright-field or fluorescence microscopy

Enciso M, López-Fernández C, Fernández JL, García P, Gosálbez A, Gosálvez J

Theriogenology. 2006; 65(2):308-16

Halosperm is an easy, available, and cost-effective alternative for determining sperm DNA fragmentation

Fernández JL, Muriel L, Goyanes V, Segrelles E, Enciso M, LaFromboise M, De Jonge C

Fertil Steril. 2005; 84(4):860

Sperm DNA fragmentation in boars is delayed or abolished by using sperm extenders

Pérez-Llano B, Enciso M, García-Casado P, Sala R, Gosálvez J

Theriogenology. 2006; 66(9):2137-43on. 2013 Jun;28(6):1707-15

Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test

Enciso M, Muriel L, Fernández JL, Goyanes V, Segrelles E, Marcos M, Montejo JM, Ardoy M, Pacheco A, Gosálvez J

 

J Androl. 2006; 27(1):106-11

Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test

Fernández JL, Muriel L, Goyanes V, Segrelles E, Gosálvez J, Enciso M, LaFromboise M, De Jonge C

Fertil Steril. 2005; 84(4):833-42