MicroBioMap®
The study of the endometrial microbiota
MicroBioMap® test is a molecular test that examines the presence of 18 pathogenic microorganisms (fungi, bacteria, and protozoa) in the endometrium, associated with the development of chronic endometritis, and also detects 4 species of Lactobacillus, described as beneficial for reproductive health.
This test detects the selected microorganisms using high-resolution quantitative PCR from an extraction of microbial DNA present in the endometrium, and establishes the level of each species normalised per human cell.
In addition to reporting the presence or absence of pathogenic microorganisms in the studied sample and their levels per human cell, the relative abundance of each of the detected microorganisms is calculated in proportion to the total microbial community identified in the sample.
ENAC | Accreditation Nº 1497/LE2766
In accordance with the requirements of the UNE-EN ISO 15189 standard, for the activities defined in the corresponding technical annex*.
MicroBioMap® is a molecular test that analyses the presence of 18 pathogenic microorganisms (fungi, bacteria, and protozoa) in the endometrium, associated with the development of chronic endometritis. Additionally, it detects 4 species of Lactobacillus, described as beneficial for reproductive health.
P+5.5 / LH+7
MicroBioMap® cryotube
(at least 4 hours)
room temperature
working days
MicroBioMap® is a molecular test that analyses the presence of 18 pathogenic microorganisms (fungi, bacteria, and protozoa) in the endometrium, associated with the development of chronic endometritis. Additionally, it detects 4 species of Lactobacillus, described as beneficial for reproductive health.
The study of the endometrial microbiota
YOUR PROCESS
Add quality and confidence to your assisted reproduction treatment: go one step further and include the MicroBioMap® test in your process.
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Description of the service
MicroBioMap® test is a molecular test that analyses the presence in the endometrium of:
• 18 pathogenic microorganisms (fungi, bacteria, and protozoa) involved in the development of chronic endometritis
• 4 species of Lactobacillus, described as beneficial for reproductive health
The study of the endometrial microbiota provides highly valuable information about the uterine environment and its suitability to receive the embryo.
The presence of pathogens in the endometrial setting has been shown to be detrimental, being associated with Chronic Endometritis (CE). CE, in turn, is a factor considered to have a high impact on implantation failures, recurrent miscarriages, and other pregnancy-related pathologies or complications.
What does MicroBioMap® test study?
The microorganisms that cause chronic endometritis analysed by the MicroBioMap® include:
The Lactobacilli profile studied includes the species:
Context
The detection of potentially pathogenic species causing EC through the MicroBioMap® test allows the clinician to choose a specific treatment for their elimination, achieving a significant improvement with this.
Furthermore, according to recent studies, the predominance of lactobacillus can be an important marker of uterine health, associated with successful reproductive outcomes. The bacterial balance in the endometrium related to the richness of Lactobacillus in this tissue is also studied using the MicroBioMap® test.
Indications
MicroBioMap® is highly useful for patients who have experienced implantation failures, recurrent miscarriages, suspected cases of EC, or for any patient undergoing an assisted reproduction cycle who wishes to improve their reproductive options.
- Cicinelli et al. 2017, ‘Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception’, Am J Reprod Immunol, 2018;79:e12782.
- Vitagliano et al. 2022, ‘Chronic Endometritis in InfertileWomen: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis’, Diagnostics, 12, 2250.
- Vomstein et al 2022, ‘Uterine microbiota plasticity during the menstrual cycle: Differences between healthy controls and patients with recurrent miscarriage or implantation failure’, J. Reprod. Immunol, 151 (2022) 103634.
- Moreno et al. 2022, ‘Endometrial microbiota composition is associated with reproductive outcome in infertile patients’, Microbiome, 10:1, 1-17.
- Benner et al 2018, ‘How uterine microbiota might be responsible for a receptive, fertile endometrium’, Hum. Reprod. Update,24:4, 393–415.