ER Map® es un nuevo test personalizado que permite determinar el estado de receptividad del endometrio durante la ventana de implantación (VI). ER Map® identifica el mejor momento del endometrio para la transferencia del embrión, aumentando la probabilidad de implantación y embarazo. ER Map® es una herramienta molecular que analiza la expresión génica de 48 genes involucrados en el desarrollo de la receptividad endometrial y la respuesta inmune materna asociada a la implantación embrionaria.
El test ER Map® permite identificar el momento óptimo del endometrio para transferir el embrión exactamente cuando hay más probabilidades de embarazo

MicroBioMap®

The study of the endometrial microbiota 

MicroBioMap® is a molecular assay that analyses the endometrium for the presence of 18 pathogenic microorganisms (fungi, bacteria, and protozoa), identified as involved in the development of chronic endometritis, and 4 lactobacillus species, identified as beneficial for reproductive health.

This test detects the selected microorganisms by quantitative PCR from an extraction of the microbial DNA present in the endometrium and determines the standardised level of each species per human cell.

In addition to determining the presence or absence of pathogenic microorganisms in the sample studied, it calculates the relative abundance of each of the microorganisms detected in proportion to the total microbial community identified in the sample.

Process

MicroBioMap® is a molecular assay that analyses the endometrium for the presence of 18 pathogenic microorganisms (fungi, bacteria, and protozoa), identified as involved in the development of chronic endometritis, and 4 lactobacillus species, identified as beneficial for reproductive health.

Biopsy of endometrial tissue
P+5.5 / LH+7

Introduction in the
MicroBio Map® cryotube

Refrigeration at 4ºC
(at least 4 hours)

Sample shipment at
room temperature

Analysis of gene
expression

Results in 20
working days

Process

MicroBioMap® is a molecular assay that analyses the endometrium for the presence of 18 pathogenic microorganisms (fungi, bacteria, and protozoa), identified as involved in the development of chronic endometritis, and 4 lactobacillus species, identified as beneficial for reproductive health.

The study of the endometrial microbiota 

YOUR PROCESS

Add quality and confidence to your assisted reproduction treatment: go one step further and include the MicroBioMap® test in your process.

1.

Tell your gynaecologist, he or she will show you how MicroBioMap® can make a difference.

2.

Your doctor will find the right option for you.

3.

Your doctor will take care of everything so that we can continue to look after you as you deserve to be in the process of becoming a mother.

Description of the service

MicroBioMap® is a molecular assay that analyses the endometrium for the presence of:

  • 18 pathogenic microorganisms (fungi, bacteria, and protozoa), identified as involved in the development of chronic endometritis.
  • 4 lactobacillus species, identified as beneficial for reproductive health.

This test detects the selected microorganisms by quantitative PCR from an extraction of the microbial DNA present in the endometrium and determines the standardised level of each species per human cell. In addition to determining the presence or absence of pathogenic microorganisms in the sample studied, it calculates the relative abundance of each of the microorganisms detected in proportion to the total microbial community identified in the sample.

What does MicroBioMap® study?

The microorganisms that cause chronic endometritis analysed by the MicroBioMap® include:

N
Atopobium vaginae | Bacteria
N
Chlamydia trachomatis | Bacteria
N
Escherichia coli | Bacteria
N
Enterococcus faecalis | Bacteria
N
Gardnerella vaginalis | Bacteria
N
Haemophilus ducreyi | Bacteria
N
Mycoplasma genitalium | Bacteria
N
Mycoplasma hominis | Bacteria
N
Neisseria gonorrhoeae | Bacteria
N
Staphylococcus aureu | Bacteria
N
Streptococcus agalactiae (group B) | Bacteria
N
Treponema pallidum (Syphilis) | Bacteria
N
Ureaplasma urealyticum | Bacteria
N
Klebsiella pneumoniae complex | Bacteria
N
Candida albicans | Fungus
N
Candida glabrata | Fungus
N
Candida tropicalis | Fungus
N
Trichomonas vaginalis | Protozoo

The lactobacilli profile studied includes the species:

N
Lactobacillus crispatus | Bacteria
N
Lactobacillus gasseri | Bacteria
N
Lactobacillus iners | Bacteria
N
Lactobacillus jensenii | Bacteria

Context

The study of the endometrial microbiota provides valuable information about the uterine environment and its ability to receive the embryo.

The presence of pathogens in the endometrial environment has been shown to be detrimental and is associated with Chronic Endometritis (CE). CE, in turn, has been associated with implantation failure, recurrent abortion, and other pathologies and pregnancy complications.

The detection of the pathogenic species that potentially cause CE using the MicroBioMap® assay makes it possible to define a specific treatment for their elimination, significantly improving the reproductive results and success rates of assisted reproductive techniques in women suffering from this condition.

According to recent studies, the predominance of lactobacilli may be an important marker of uterine health, associated with successful reproductive outcomes.

The bacterial balance in the endometrium in relation to the richness of lactobacillus in this tissue is also studied using the MicroBioMap® assay.

 

Indications

MicroBioMap® is especially indicated for patients with implantation failures, recurrent abortions, suspected chronic endometritis, or any patient undergoing an IVF cycle who wants to improve their reproductive success.