Fertility Treatments: Improving Pregnancy Rates and Reducing Complications

In the realm of assisted reproduction, the effective management of treatments and medications is key to increasing success rates in pregnancies. A recent study has highlighted the efficacy of tacrolimus in women with fertility issues, showing a significant improvement in pregnancy rates and a reduction in obstetric complications. This article explores the role of tacrolimus in fertility treatments and how it complements advanced testing like the Im Map® test from igls.net.

Tacrolimus: A Boost for Pregnancy Rates The study published by Nakagawa and colleagues reveals that women treated with tacrolimus experience significantly higher pregnancy rates compared to those who do not receive this treatment. Tacrolimus, a commonly used immunosuppressant, appears to play a crucial role in improving the odds of conceiving, especially in women with a history of fertility issues. This information is vital for fertility specialists seeking to optimise treatments for their patients.

Tacrolimus in Women with High Prolactin (PRL) Among women with elevated levels of prolactin (PRL), the use of tacrolimus was associated with lower rates of biochemical pregnancy but an increase in live birth rates. This suggests that tacrolimus could be particularly beneficial in certain patient subgroups, such as those with hormonal disorders affecting fertility. Tacrolimus’s ability to improve pregnancy outcomes in these cases opens new avenues in the personalised treatment of infertility.

Managing Obstetric Complications and Complementing with Im Map® Test The administration of tacrolimus during pregnancy has also proven effective in managing serious previous obstetric complications. This finding is particularly relevant for women who have experienced obstetric problems in previous pregnancies, such as pre-eclampsia or recurrent spontaneous abortions. Complementing these treatments with the Im Map® test, which evaluates the maternal endometrial immune profile, can provide a more comprehensive and personalised perspective for each patient. By analysing the endometrial immune system, Im Map® helps to identify potential imbalances that could affect implantation and pregnancy development, allowing for a more holistic and personalised therapeutic approach.


The use of tacrolimus in fertility treatments represents a significant advancement, improving pregnancy rates and reducing obstetric complications. In combination with advanced testing like the Im Map® test, fertility specialists can offer treatment more tailored to the individual needs of each patient. This integration of pharmacology and genetic diagnostics is marking a turning point in the field of assisted reproduction, opening doors to a future where every fertility treatment is as unique as the patient receiving it.