Spermxpression® transforming the diagnosis of male infertility

Male infertility, accountable for up to 50% of cases in couples facing difficulties conceiving, is a complex field requiring advanced diagnostic tools for accurate evaluation. SpermXpression®, a molecular test available at igls.net, offers an innovative approach in the analysis of male infertility, beyond conventional semen analysis. This article examines how SpermXpression® significantly contributes to the diagnosis and treatment of male infertility.

Beyond Conventional Semen Analysis:


The Importance of SpermXpression® While traditional semen analyses, such as sperm concentration, motility, and morphology, are important, they do not address all factors that can influence sperm quality. SpermXpression® provides a deeper evaluation, focusing on the expression of protamines, essential proteins for the correct packaging and protection of sperm DNA. Alterations in the proportion of these protamines are commonly related to poor sperm quality and a decrease in fertility.


What is SpermXpression® and How Does It Improve Fertility Outcomes?


SpermXpression® uses quantitative PCR technology to analyze the expression of protamine 1 and 2 genes in a seminal sample. By determining whether the proportion of these proteins is within normal values, this test provides valuable information that can influence male fertility. It is especially useful for patients who have experienced failed IVF cycles or reduced rates of blastocyst development, helping doctors to select the best treatment strategies, such as IVF, ICSI, TESA, TESE, or the use of donor sperm.


Benefits and Clinical Applications of SpermXpression®


The benefits of SpermXpression® include more precise identification of the underlying causes of male infertility, allowing for a more informed selection of assisted reproduction treatments. The results of this test can be decisive in choosing specific fertilization techniques, such as IVF or ICSI, and can guide the consideration of procedures like TESA or TESE in cases of severe infertility.





SpermXpression® represents a significant advance in the diagnosis and treatment of male infertility. By providing a more detailed analysis of sperm quality, this test improves the chances of success in assisted reproduction treatments. Its innovative and comprehensive approach is a clear example of how genetics and reproductive immunology are transforming the field of fertility, offering new hopes and options to couples facing reproductive challenges.

Advanced male

infertility diagnosis